immunoadjuvant Drug Delivery
Our group looks at intratumoral immunoadjuvant delivery via locoregional techniques with a focus on bone cements and hydrogel based depots for both intra-parenchymal and intra-arterial delivery.
ImmunoBone
A bone cement platform that builds on ImmunoGel to induce immunotherapy and ability to deliver pulsatile immunoadjuvants to bone metastasis.
Gene Delivery
Locoregional Gene Therapy -
For oncology, in collaboration with the Hockenbery and Storfer Labs, our group is evaluating the ability to deliver genes to induce competitive apoptosis with non-viral and viral based delivery. Historically, gene therapy has struggled with poor penetration and conversion as well as systemic non-specific effects. Locoregional delivery combined with the Hockenbery and Storfer discovery of competitive apoptosis may allow for gene therapy to finally make an impact in cancer.
For pulmonary endovascular disease, such as HHT and pulmonary hypertension, we are exploring methods for endovascular drug and gene delivery, in collaboration with Dr. Sam Rayner.